Crystal Engineering in Continuous Plug-Flow Crystallizers
نویسندگان
چکیده
منابع مشابه
Crystal Engineering in Continuous Plug-Flow Crystallizers
Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise co...
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This study presents the development of a plug flow crystallization (PFC) platform consisting of a vortex mixer combined with a tubular reactor. Process analytical technologies (FBRM, PVM, FT-IR) were applied in-situ in order to characterize and optimize crystallizations via the use of novel flow cells. In addition to this a new calibration free method for concentration monitoring was successful...
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Crystallization processes in the pharmaceutical industry are usually designed to obtain crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process conditions required to fabricate crystals with controlled characteristics is critical during process development. In this work, continuous crystallization of Ketoconazole, Flufenamic Acid, and L-Glutamic Acid in a no...
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Protein crystals have many important applications in many fields, including pharmaceutics. Being more stable than other formulations, and having a high degree of purity and bioavailability, they are especially promising in the area of drug delivery. In this contribution, the development of a continuously operated tubular crystallizer for the production of protein crystals has been described. Us...
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The desired bioavailability and the method of drug administration and delivery can require stringent control on the crystal size distribution. Optimal control strategies are proposed to manufacture crystals with a targeted size distribution by combining controlled seeding by impinging jet crystallization with a batch crystallizer operating at a controlled constant growth rate. The same strategi...
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ژورنال
عنوان ژورنال: Crystal Growth & Design
سال: 2017
ISSN: 1528-7483,1528-7505
DOI: 10.1021/acs.cgd.7b01096